Sign in Register. Raised GGT levels have been reported in a variety of clinical conditions including 1 : pancreatic disease myocardial infarction chronic obstructive pulmonary disease renal failure diabetes obesity alcoholism Drugs such as phenytoin and barbiturates may cause high GGT levels 2.
Role of gamma-glutamyl transpeptidase activity in the diagnosis of hepatobiliary disease. Digestion, 12, Plasma gamma-glutamyl transpeptidase elevation in patients receiving enzyme - inducing drugs.
Lancet, 2, Register Sign In. Test Catalog Account. Outreach Solutions Tactics Articles Events. Utilization Management Algorithms. Test Catalog. Download Test. Useful For Suggests clinical disorders or settings where the test may be helpful Diagnosing and monitoring hepatobiliary disease, it is currently the most sensitive enzymatic indicator of liver disease Ascertaining whether observed elevations of alkaline phosphatase are due to skeletal disease normal gamma-glutamyltransferase: GGT or reflect the presence of hepatobiliary disease elevated GGT A screening test for occult alcoholism.
WB Saunders Company, Philadelphia, 2. Having mild liver disease such as hepatitis C or fatty liver does not increase the risk that a given medication will be toxic to the liver, however, if a person with pre-existing liver disease happens to develop liver injury from a medication, the resulting liver damage may be more severe than would occur in an otherwise healthy person with the same reaction.
Often physicians may be reluctant to start patients on a cholesterol lowering medication if the liver tests are already mildly elevated; usually due to fatty liver disease. Research has shown that cholesterol lowering medications are safe in people with fatty liver disease or mild hepatitis C infection, and in fact, may be beneficial to the liver by decreasing inflammation. People with more severe types of liver disease such as cirrhosis have to be more careful regarding the types and dose of medications they take.
While the ability of the liver to properly break down and utilize medications is preserved even when severe liver disease is present, there are some medications that should not be used or should be used at reduced dose when given to patients with advanced cirrhosis.
Jorge L. Updated December Digestive Health Topics A-Z. Basics Print. Overview One of the main functions of the liver is to break down substances that we take by mouth, including medications, herbs and supplements. Symptoms In most cases substantial liver damage can occur before symptoms appear. Diagnosis Liver damage of any type is usually detected by doing blood tests. Medication Use in People with Liver Disease With very rare exceptions, people that have mild liver disease can safely take most common prescription and non-prescription medications at the recommended dose.
Recommendations to Minimize the Risk of Liver Injury from Medications Always keep a list of all the prescription and non-prescription medications that you take, including herbs, vitamins and supplements.
The fewer medications you take the better. This includes herbs, supplements, prescription and non-prescription medications. If you have several physicians prescribing medications for you, be sure all of them are updated on your current list of medications.
When using non-prescription medications, be sure to read the label carefully and never exceed the recommended amount. Avoid taking the maximum recommended dose for a prolonged period without consulting a physician. However, liver biopsies in patients with solitary GGT elevations seldom show irreversible hepatic injury. Social drinking does not elevate GGT, but chronic alcohol consumption induces the synthesis of GGT more than alkaline phosphatase.
Pancreatitis also causes moderate elevations in GGT activity. Patients with diabetes, hyperthyroidism, rheumatoid arthritis, and obstructive pulmonary disease often have an increased GGT, but the reason for this elevation is unknown.
Phenytoin may cause levels to increase 5 fold.
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